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The GO terms illustrate the protein's functions, cellular locations, and processes it is involved in. UniProtKB and PDB accession numbers are included to link to additional resources. As for many moonlighting proteins, several names of the protein are included in the entry so that the corresponding entries can be found by users using different names. ACE2 is a moonlighting protein because it is both (1) an enzyme that cleaves angiotensin to produce bioactive peptides and (2) a chaperone that helps in the proper folding and plasma membrane targeting of the BoAT amino acid transporter. Published by Oxford University Press on behalf of Nucleic Acids Research.Įxample of information included in the annotation for the human Angiotensin-Converting Enzyme 2 (ACE2), which is the Sars-Cov2 coronavirus target. More kinds of information about the proteins and the species in which they have multiple functions has been added, including CATH and SCOP classification of structure, known and predicted disorder, predicted transmembrane helices, type of organism, relationship of the protein to disease, and relationship of organism to cause of disease. The new entries include more examples from humans, plants and archaea, more proteins involved in disease and proteins with different combinations of functions.
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For this release, the number of proteins annotated has been expanded to over 500 proteins and dozens of protein annotations have been updated with additional information, including more structures in the Protein Data Bank, compared with version 2.0. Here, we describe an expansion in the database since our previous report in the Database Issue of Nucleic Acids Research in 2018. Moonlighting proteins have two or more physiologically relevant distinct biochemical or biophysical functions performed by a single polypeptide chain. MoonProt 3.0 () is an updated open-access database storing expert-curated annotations for moonlighting proteins.